- Program Years: 1993-1997
- Academic Institution: Duke University
- Field of Study: Biomedical Engineering: Cardiac Electrophysiology
- Academic Advisor: Craig Henrique
Oak Ridge National Laboratory (1994)
Ph.D. Biomedical Engineering, Duke University, 2002
M.S. Nuclear Engineering, North Carolina State University, 1995
B.S. Nuclear Engineering, North Carolina State University, 1993
Status: Director, Quantitative Clinical Pharmacology - Astrazeneca Pharmaceuticals
Research Area: Computational and Statistical Modeling of Pharmacokinetic/Pharmacodynamic Systems for Biopharma
Contact Information: firstname.lastname@example.org
Population PK modeling of vildagliptin and major metabolites in patients with and without renal impairment. Kaila N, Ebling WF, Penland RC, Sarangapani R. In preparation.
Preclinical evaluation of cardiac sodium channel-mediated adverse effects. Erdemli G, Kim AM, Ju H, Springer C, Penland RC, Hoffmann PK. Society of Toxicology, 2013, accepted.
Cardiac safety implications of hNav1.5 blockade and a framework for preclinical evaluation. Erdemli G, Kim AM, Ju H, Springer C, Penland RC, Hoffmann PK. Frontiers in Pharmaceutical Medicine and Outcomes Research, 3(6): 1-9, 2012.
From particles to patients: An industrial perspective of the application of IVIVC for dose projection. Mueller-Zsigmondy M, Meier U, Saigne S, Penland RC, Heimbach T, Lin W, Li S, John E, Schuleit M, Becker D. accepted 8th World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology. Istanbul, Turkey, March 2012.
Systems Toxicology Modeling for Prediction in Humans. Migliorini C, Lave T, Parrott NJ, Reddy M, Grimm HP, Penland RC, Soubret A, Helmlinger G, Georgieva A and Zuideveld KP. General, Applied and Systems Toxicology, 2011.
Models for integrative assessment of proarrhythmic risk in novel therapeutics. Penland RC. Invited lecture at Vertex Pharmaceuticals. July 2008.
Discovery and development of novel Kv1.5 inhibitors for atrial fibrillation. Penland RC. Ion Channel Targets, Boston, MA, 2006.
Bottino DC, Penland RC, Stamps A, Traebert M, Dumotier B, Georgieva A, Helmlinger G, Lett GS. Preclinical cardiac safety assessment of pharmaceutical compounds using an integrated systems-based computer model of the heart. Prog Biophys Mol Bio: Focused Issue on Integrative Physiology, 90(1), 2006.
Reconciling Discrepancies Between Channel-Level and Tissue-Level Cardiotoxicity Signals: A Model-Based Approach. Bottino D, Lett GS, Stamps A, Penland RC, Georgieva A, Helmlinger G, Hoffman P CHI World Pharmaceutical Congress, Philadelphia, PA, 2004.
Indirect observation of molecular-level drug effects from cell-level readouts: applications of Model-Based Assays. Bottino D, Lett GS, Kleinstein S, Cho C, Penland RC, Stamps A. Beyond Genome, Systems Biology, San Diego, CA, 2003.
Using in silico biology to facilitate drug development. Levin JM, Penland RC, Stamps AT, Cho CR. Novartis Found Symp, 247:222-238, 2002.
Penland RC, Harrild DM, Henriquez CS. Modeling impulse propagation and extracellular potential distributions in anisotropic cardiac tissue using a finite volume element discretization. Comput Vis Sci, 4:215-226, 2002.
Muzikant AL and Penland RC. Models for profiling the potential QT prolongation risk of drugs. Curr opin Drug Disc Dev, 5:127-135, 2002.
Harrild DM, Penland RC, Henriquez CS. A flexible method for simulating cardiac conduction in three-dimensional complex geometries. J Electrocard, 33:241-251, 2000.
PATENTS & APPLICATIONS
Dosage Regimen for the Administration of Elinogrel, application 61/549,898
Thiotriazolyl Derivatives, application 11/546,942. Filed 10/12/06
S1P Receptor Modulating Compounds and Use Thereof, application 11/917,766. Filed 7/24/06
Thioxothiazolidine Derivatives, application 60/615,873
Novartis SPOT Award for outstanding contributions
NSF Emerging Cardiovascular Technology Fellow
James B. Duke University Fellow
Department of Energy Computational Science Graduate Fellow
American Nuclear Society Graduate Fellow
North Carolina State University Award for Outstanding Scholarly Achievement
North Carolina State University Deanâ€™s Fellow