Pauline Ng

  • Program Years: 2000-2002
  • Academic Institution: University of Washington
  • Field of Study: Bioengineering
  • Academic Advisor: Steven Henikoff
  • Practicum(s):
    Argonne National Laboratory (2001)
  • Degree(s):
    Ph.D. Bioengineering, University of Washington, 2002
    B.S. Biology, California Institute of Technology, 1997

Current Status

  • Status: Group Leader, Genome Institute of Singapore
  • Research Area: Computational Biology
  • Personal URL:


2002-2006, Senior Scientist, Illumina
2006-2010, Assistant Professor, J. Craig Venter Institute
2010-present, Group Leader, Genome Institute of Singapore


Vaser R, Adusumalli S, Leng SN, Sikic M, Ng PC "SIFT missense predictions for genomes." Nat Protoc 2016 Jan ; 11(1) : 1-9 Epub 2015 Dec 3

Adusumalli S, Lee H, Hoi Q, Koo SL, Tan IB, Ng PC "Assessment of Web-Based Consumer Reviews as a Resource for Drug Performance." J Med Internet Res 2015 ; 17(8) : e211

Javed A, Agrawal S, Ng PC "Phen-Gen: combining phenotype and genotype to analyze rare disorders." Nat Methods 2014 Sep ; 11(9) : 935-7 Epub 2014 Aug 3

Ng PC, Murray SS, Levy S. Venter JC (2009) "An agenda for personalized medicine" Nature 461:724-726.

Harismendy O*, Ng PC*, Strausberg RL, Wang X, Stockwell TB, Beeson KY, Schork NJ, Murray SS, Topol EJ, Levy S, Frazer KA "Evaluation of next generation sequencing platforms for population targeted sequencing studies." Genome Biol 2009 ; 10(3) : R32. *These authors contributed equally. Epub 2009 Mar 27

Ng PC, Zhao Q, Levy S, Strausberg RL, Venter JC "Individual genomes instead of race for personalized medicine." Clin Pharmacol Ther 2008 Sep ; 84(3) : 306-9.

Ng PC, Levy S, Huang J, Stockwell TB, Walenz BP, Li K, Axelrod N, Busam DA, Strausberg RL, Venter JC "Genetic variation in an individual human exome." PLoS Genet 2008 ; 4(8) : e1000160

Levy S, Sutton G, Ng PC, Feu k L, Halpern AL, Walenz BP, Axelrod N, Huang J, Kirkness EF, Denisov G, Lin Y, MacDonald JR, Pang AW, Shago M, Stockwell TB, Tsiamouri A, Bafna V, Bansal V, Kravitz SA, Busam DA, Beeson KY, McIntosh TC, Remington KA, Abril JF, Gill J, Borman J, Rogers YH, Frazier ME, Scherer SW, Strausberg RL, Venter JC "The diploid genome sequence of an individual human." PLoS Biol 2007 Sep 4 ; 5(10) : e254

Ng PC, Henikoff S "Predicting the effects of amino acid substitutions on protein function." Annu Rev Genomics Hum Genet 2006 ; 7 : 61-80.

Ng, P.C. and Henikoff, S. SIFT: Predicting amino acid changes that affect protein function. Nucleic Acids Res. 2003 Jul 1;31(13):3812-4.

Ng, P.C. and Henikoff, S. Accounting for human polymorphisms predicted to affect protein function. Genome Res. 2002 Mar;12(3):436-46.

Ng, P.C. and Henikoff, S. Predicting deleterious amino acid substitutions. Genome Res. 2001 May;11(5):863-74.

Ng, P.C., Henikoff, J.G., and Henikoff, S.
PHAT: a transmembrane-specific substitution matrix. Predicted hydrophobic and transmembrane. Bioinformatics. 2000 Sep;16(9):760-6.