Bree Aldridge

  • Program Years: 2002-2006
  • Academic Institution: Massachusetts Institute of Technology
  • Field of Study: Computational Biology
  • Academic Advisor: Douglas Lauffenburger
  • Practicum(s):
    Pacific Northwest National Laboratory (2004)
  • Degree(s):
    Ph.D. Biological Engineering, Massachusetts Institute of Technology, 2008
    B.S. Computer Engineering, University of Arizona, 2002
    B.S. Molecular and Cellular Biology, University of Arizona, 2002

Current Status


Wirth, S.E., Krywy, J.A., Aldridge, B.B., Fortune, S.M., Fernandez-Suarez, M., Gray, T.A., Derbyshire, K.M., "Polar assembly and scaffolding proteins of the virulence-associated ESX-1 secretory apparatus in mycobacteria.” Molecular Microbiology, 2012, 83(3):654-664.

Aldridge, B.B.*, Fernandez-Suarez, M.*, Heller, D., Ambravaneswaran, V., Irimia, D., Toner, M., Fortune, S.M., “Asymmetry and aging in mycobacterial cells lead to variable growth and antibiotic susceptibility.” Science, 2012, 335 (6064): 100-104.

Aldridge, B.B.*, Gaudet, S.*, Lauffenburger, D.A., Sorger, P.K., “Lyapunov exponents and phase diagrams reveal multi-factorial control over TRAIL-induced apoptosis.” Molecular Systems Biology, 2011, 7:553.

Aldridge, B.B., Saez-Rodriguez, J., Muhlich, J.L., Sorger, P.K., Lauffenburger, D.A., Fuzzy logic analysis of kinase pathway crosstalk in TNF/EGF/Insulin-induced signaling. PLoS Computational Biology, 2009, 5(4): e1000340.

Albeck, J.G., Burke, J.M., Aldridge, B.B., Zhang, M.S., Lauffenburger, D.A., Sorger, P.K. €œQuantitative analysis of pathways controlling extrinsic apoptosis in single cells.” Mol. Cell, 2008, 30(1):11-25.

Aldridge, B.B., Burke, J., Lauffenburger, D., Sorger, P. €œPhysicochemical Modelling of Cell Signaling Pathways.” Nature Cell Biol, 2006, 8:1195-2003.

Aldridge, B.B., Haller, G., Sorger, P., and Lauffenburger, D. “Direct Lyapunov exponent analysis enables parametric study of transient signalling governing cell behaviour.” Systems Biology, 2006. 153 (6).

Draviam VM, Shapiro I, Aldridge B., and Sorger PK. €œMisorientation and reduced stretching of aligned sister kinetochores promote chromosome missegregation in EB1- or APC-depleted cells.” EMBO Journal, 2006. 25 (12): 2814-27.