Towards quantitative biology: High-throughput analysis of transcription factor binding preferences.

Robin Friedman, Massachusetts Institute of Technology


Traditionally, biology has been limited by experimental techniques to be a qualitative science, but new technologies are enabling massive increases in the amount of data available to biologists. New quantitative and statistical approaches are required for making sense of these data. Here we present a technique that leverages sequencing technology to provide comprehensive quantitation of transcription factor binding specificity, a key factor in understanding gene expression.

Abstract Author(s): Robin Friedman, Razvan Nutiu, Shujun Luo, Gary Schroth, Christopher Burge