Amanda Randles is the Alfred Winborne Mordecai and Victoria Stover Mordecai Associate Professor of Biomedical Sciences and Biomedical Engineering at Duke University, where she also serves as Director of the Duke Center for Computational and Digital Health Innovation. She holds courtesy appointments in Mechanical Engineering and Materials Science, Computer Science, and Mathematics, and is a member of the Duke Cancer Institute. Her research focuses on the development of patient-specific digital twin models that integrate high performance computing, machine learning, and multiscale biophysical simulations to enable proactive diagnosis and treatment of diseases ranging from cardiovascular disease to cancer. She has published 113 peer-reviewed papers, including in Science, Nature Biomedical Engineering, and Nature Digital Medicine, and holds 121 granted U.S. patents with approximately 75 additional applications pending. Her contributions have been recognized with the ACM Prize in Computing, the NIH Pioneer Award, the NSF CAREER Award, the ACM Grace Hopper Award, the Jack Dongarra Early Career Award, and the inaugural Sony and Nature Women in Technology Award. She was named to the HPCwire People to Watch list in 2025, is a Fellow of the National Academy of Inventors, and has been honored as a World Economic Forum Young Scientist and one of MIT Technology Review’s Top 35 Innovators Under 35. Randles received her Ph.D. in Applied Physics from Harvard University as a DOE Computational Science Graduate Fellow and NSF Fellow, an M.S. in Computer Science from Harvard, and a B.S. in Computer Science and Physics from Duke. Prior to graduate school, she worked as a software engineer at IBM on the Blue Gene supercomputing team.
