Sylvia Hanna

  • Program Year: 4
  • Academic Institution: Northwestern University
  • Field of Study: Inorganic and Materials Chemistry
  • Academic Advisor: Omar Farha
  • Practicum(s):
    Sandia National Laboratories, New Mexico (2021)
  • Degree(s):
    B.S. Physical Chemistry, Rowan University, 2017

Summary of Research

Actinide ions and other toxic compounds based on ions such as technetium and caesium are widely present in the United States’ nuclear deterrent stockpile and legacy waste. It is thus vital to dedicate significant research efforts towards both (1) understanding the fundamental chemical properties of actinide species and (2) capturing hazardous radioactive compounds.

An optimal platform to address both of these objectives is a metal-organic framework (MOF). A unique class of scientifically intricate, architecturally striking, and artistically exquisite structures, MOFs integrate the diversity and tunability of organic molecules and the structural integrity of inorganic compounds into crystalline, porous networks. MOFs are composed of inorganic nodes and organic linkers which self-assemble into chemically diverse structures with typically high surface areas. The high stability and well-defined coordination environments inherent to metal-organic frameworks (MOFs) make them useful in both of my targeted objectives.

(1) Incorporating actinide ions into MOFs will assist in better understanding the coordination chemistry and reactivity of actinide ions. However, most MOFs are based on transition metal or lanthanide nodes, and the analogous design rules for actinide MOFs are lacking. Thus, I focus on developing design rules for uranium MOFs by predicting and controlling topologies through synthesis techniques and examining the structure–property relationships of the resulting MOFs.

(2) Exceptionally stable zirconium-based MOFs have shown promising abilities to capture toxic compounds from radioactive waste. However, if these MOFs are unable to remain stable in the presence of high radiation, their ability to capture hazardous compounds will be ineffective. Thus, I expose these MOFs to significant radiation levels and demonstrate their stability levels under these harsh conditions.

Publications

Publications

Kirlikovali, K. O.*; Hanna S. L.*; Son, F.*; Farha, O. K. Back to the Basics; Developing Advanced Metal-Organic Frameworks Using Fundamental Chemistry Concepts. ACS Nanoscience Au. 2022. Under Review.

Hanna, S. L.; Debela, T. T.; Mroz, A.; Syed, Z. H.; Kirlikovali, K. O.; Hendon, C. H.; Farha, O. K. Identification of a Metastable Uranium Metal-Organic Framework Isomer Through Non-Equilibrium Synthesis. Chem. Sci. 2022, Advance Article.

Hastings, A; Ray, D.; Hanna, S. L.; Jeong, W.; Chen, Z.; Oliver, A.; Gagliardi, L.; Farha, O. Hixon, A. Leveraging Nitrogen-Linkages in the Formation of a Porous Thorium–Organic Nanotube Suitable for Iodine Capture. Inorg. Chem. 2022, 61, 9480-9492.

Su, S.; Jung, D.; Gong, X.; Idrees, K.; Hanna, S. L.; Islamoglu, T.; Gianneschi, N.; Farha, O. K. Aggregation-Suppressed Porous Processable Hexa-Zirconium/Polymer Composites for detoxification of a Nerve Agent Simulant. Chem. Mater. 2022, 34, 4983-4991.

Hanna, S. L. The Discovery of Charged Point-Point Repulsions: A Lesson in Storytelling. Chem 2022, 8, 3-4.

Hanna, S. L.; Chheda, S.; Anderson, R.; Ray, D.; Malliakas, C. D.; Knapp, J. G.; Otake, K.; Li, Peng; Li, Penghao; Wang, X.; Wasson, M. C.; Zosel, K.; Evans, A. M.; Robison, L.; Islamoglu, T.; Zhang, X.; Dichtel, W. R.; Stoddart, J. F.; Gomez-Gualdron, D. A.; Gagliardi, L.; Farha, O. K. "Spontaneous De-Interpenetration Through Charged Point-Point Repulsions," Chem 2022, 8, 225-242.

Fairley, M.; Gilson, S.; Hanna, S. L.; Mishra, A.; Knapp, J.; Idrees, K.; Chheda, S.; Traustason, H.; Islamoglu, T.; Burns, P.; Gagliardi, L.; Farha, O. K.; LaVerne, J. "Linker Contribution Towards Stability of MetalꟷOrganic Frameworks Under Ionizing Radiation," Accepted at Chem. Mater. 2021.

Gilson, S.; Fairley, M.; Hanna, S. L.; Szymanowski, J.; Julien, P.; Chen, Z.; Farha, O. K.; LaVerne, J.; Burns, P. "Unusual Metal–Organic Framework Topology and Radiation Resistance through Neptunyl Coordination Chemistry," J. Am. Chem. Soc. 2021, 143, 17354-17359.

Cao, R.; Chen, Z.; Chen, Y.; Idrees, K. B.; Hanna, S. L.; Wang, X.; Goetjen, T. A.; Sun, Q.; Islamoglu, T.; Farha, O. K. "Benign Integration of a Zn-Azolate Metal-Organic Framework onto Textile Fiber for Ammonia Capture," ACS Appl. Mater. Inter. 2020, 12, 47747-47753.

Gilson, S. E.; Fairley, M.; Julien, P.; Oliver, A. G.; Hanna, S. L.; Arntz, G.; Farha, O. K.; LaVerne, J. A.; Burns, P. C. "Unprecedented Radiation Resistant Thorium-Binaphthol Metal-Organic Framework," J. Am. Chem. Soc. 2020, 142, 13299-13304.

Farha, O. K.; Zhang, X.; Knapp J. K.; Hanna, S. L.; Chen, Z.; Li, P.; "Coordination Chemistry in the Structural and Functional Exploration of Actinide-Based Metal-Organic Frameworks," Bulletin of Japan Society of Coordination Chemistry 2020, 75, 3-12.

Son, F. A.; Wasson, M. C.; Islamoglu, T.; Chen, Z.; Gong, X.; Hanna, S. L.; Lyu, J.; Wang, X.; Idrees, K.; Mahle, J. J.; Peterson, G. W.; Farha, O. K. "Uncovering the Role of Metal-Organic Framework Topology on the Capture and Reactivity of Chemical Warfare Agents," Chem. Mater. 2020, 32, 11, 4609-4617.

Hanna, S. L.; Rademacher, D. X.; Hanson, D. J.; Islamoglu, T.; Olszewski, A. K.; Nenoff, T. M.; Farha, O. K. Structural Features of Zirconium-Based Metal-Organic Frameworks Affecting Radiolytic Stability," Ind. Eng. Chem. Res. 2020, 59. 7520-7526.

Zhang, X.; Chen, Z.; Liu, X.; Hanna, S. L.; Wang, X.; Taheri-Ledari, R.; Maleki, A.; Li, P.; Farha, O. K. "A historical overview of the activation and porosity of metal-organic frameworks," Chem. Soc. Rev. 2020, 49, 7406-7427.

Maldonado, R. R.; Zhang, X.; Hanna, S. L.; Gong, X.; Gianneschi, N. C.; Hupp, J. T.; Farha, O. K. "Squeezing the box: isoreticular contraction of pyrene-based linker in a Zr-based metal-organic framework for Xe/Kr separation," Dalton Trans. 2020, 49, 6553-6556.

Knapp, J. G; Zhang, X.; Elkin, T.; Wolfsburg, L. E.; Hanna, S. L.; Son, F. A.; Scott, B. L.; Farha, O. K. "Single Crystal Structure and Photocatalytic Behavior of Grafted Uranyl on the Zr-Node of a Pyrene-Based Metal-Organic Framework," CrystEngComm 2020, 22, 2097-2102.

Chen, Z; Hanna, S. L.; Redfern, L. R.; Alezi, D.; Islamoglu, T.; Farha, O. K. "Reticular Chemistry in the Rational Synthesis of Functional Zirconium Cluster-Based MOFs," Coordination Chemistry Reviews 2019, 386, 32-49.

Li, P.; Wang, X.; Otake, K.; Lyu, J.; Hanna, S. L.; Islamoglu, T.; Farha, O. K. "Synthetic Control of Thorium Polyoxo-Clusters in Metal-Organic Frameworks toward New Thorium-Based Materials," ACS Applied Nanomaterials 2019, 2, 2260-2265.

Li., P.; Goswami, S.; Otake, K.; Wang, X.; Hanna, S. L.; Farha, O. K. "Stabilization of an Unprecedented Hexanuclear Cluster in a Thorium-Organic Framework," Inorganic Chemistry 2019, 58(6), 3586-3590.

Hanna, S. L.; Xuan, Z.; Otake, K.; Drout, R. J.; Li, P.; Islamoglu, T.; Farha, O. K. "Guest dependent Single-Crystal-to-Single-Crystal Phase Transitions in a 2D Uranyl-Based Metal-Organic Framework," Crystal Growth & Design 2019, 19 (1), 506-512.

Drout, R. J.; Robison, L.; Hanna, S; Farha, O. K., "Can Metal-Organic Framework Composites Contain the Water Contamination Crisis?" ACS Central Science 2018, 4,321-323.

Hanna, S. L.; Huang, J. L.; Swinton, A. J.; Caputo, G. A.; Vaden, T. D.,"Synergistic Effects of Polymyxin and Ionic Liquids on Lipid Vesicle Membrane Stability and Aggregation," Biophysical Chemistry 2017, 227, 1-7.

Miller, M. C.; Hanna, S. L.; DeFrates, K. G.; Fiebig, O. C.; Vaden, T. D."Kinetics and Mass Spectrometric Measurements of Myoglobin Unfolding in Aqueous Ionic Liquid Solutions," International Journal of Biological Macromolecules 2016, 85, 200-207.

Presentations:
1. Discovery of Spontaneous De-interpenetration Through Charged Point-Point Repulsions. 8th International Conference on Metal–Organic Frameworks and Open Framework Compounds. Dresden, Germany. 2022.
2. Discovery of Spontaneous De-interpenetration Through Charged Point-Point Repulsions. CAS Future Leaders Symposium. Columbus, OH. 2022.
3. Discovery of Spontaneous De-interpenetration Through Charged Point-Point Repulsions. American Chemical Society National Meeting, Spring 2022. Chicago, IL. 2022.
4. Discovery of Spontaneous De-interpenetration Through Charged Point-Point Repulsions. DOE NNSA SSGF and LRGF Annual Program Meeting. Santa Fe, NM. 2022.
5. Discovery of Spontaneous De-interpenetration Through Charged Point-Point Repulsions. Bimonthly Organic Solid-State Symposium. Virtual. 2022 (Invited Speaker).
6. Mapping the Phase Space of Uranium-Based Materials. NNSA Stewardship Science Academic Programs Symposium. Virtual. 2022.
7. Facile Impregnation of Size-Restricted Metal Nanoparticles in Zeolites for Acid Gas Adsorption. Sandia National Laboratories, Research Seminar. Albuquerque, NM. 2021.
8. Dynamic Structural Transformations of Uranium-Based Metal–Organic Frameworks. Pfizer Chemistry Connect. Virtual. 2021.
9. Discovery of Spontaneous De-Interpenetration Through Charged Point-Point Repulsion. 3M RISE Symposium. Virtual. 2021 (Invited Speaker).
10. Structural Features of Zirconium-Based Metal–Organic Frameworks (MOFs) Affecting Radiolytic Stability. MOFs for Energy and the Environment Faraday Discussion. Virtual. 2021.
11. Structural Features of Zirconium-Based Metal–Organic Frameworks Affecting Radiolytic Stability. American Chemical Society National Meeting, Spring 2021. Virtual. 2021.
12. Discovery of Spontaneous De-Interpenetration Through Charged Point-Point Repulsions. NNSA Stewardship Science Academic Programs Symposium. Virtual. 2021 (Outstanding Poster Award).
13. Structural Features of Zirconium-Based Metal–Organic Frameworks (MOFs) Affecting Radiolytic Stability. NNSA Stewardship Science Academic Programs Symposium. Washington DC. 2020.
14. Guest-Dependent Single-Crystal-to-Single Crystal Phase Transitions in a Two-Dimensional Uranyl-Based Metal–Organic Framework. American Chemical Society National Meeting, Fall 2019. San Diego, CA. 2019.
15. Guest-Dependent Single-Crystal-to-Single-Crystal Phase Transitions in a Two-Dimensional Uranyl-Based Metal–Organic Framework. Gordon Research Seminar, Nanoporous Materials and Their Applications. Andover, New Hampshire. 2019.
16. Guest-Dependent Single-Crystal-to-Single-Crystal Phase Transitions in a Two-Dimensional Uranyl-Based Metal–Organic Framework. Gordon Research Conference, Nanoporous Materials and Their Applications. Andover, New Hampshire. 2019.
17. Guest-Dependent Single-Crystal-to-Single-Crystal Phase Transitions in a Two-Dimensional Uranyl-Based Metal–Organic Framework. DOE NNSA SSGF and LRGF Annual Program Meeting. Washington DC. 2019.
18. Developing Design Rules for F-block Metal–Organic Frameworks. 6th International Conference on Metal–Organic Frameworks and Open Framework Compounds. Auckland, New Zealand. 2018.
19. Synergistic Antimicrobial Effects of Aqueous Ionic Liquids and Polymyxin on Lipid Vesicles. Rowan University Annual STEM Symposium. Glassboro, NJ. 2017.
20. Effects of Aqueous Ionic Liquids on the Structures and Unfolding Kinetics of Myoglobin and Trypsin Proteins. American Chemical Society National Meeting, Fall 2016. Philadelphia, PA. 2016.
21. Characterization of Antibiotics and Lipid Vesicles in Aqueous Ionic Liquid Solutions. American Chemical Society Mid-Atlantic Regional Meeting. Riverdale, NY. 2016.
22. Characterization of Antibiotics and Lipid Vesicles in Aqueous Ionic Liquid Solutions. Rowan University Summer Undergraduate Research Program Symposium. Glassboro, NJ. 2016.
23. Characterization of Antibiotics and Lipid Vesicles in Aqueous Ionic Liquid Solutions. Rowan University Annual STEM Symposium. Glassboro, NJ. 2016.
24. Characterization of Antibiotics and Lipid Vesicles in Aqueous Ionic Liquid Solutions. South Jersey American Chemical Societ

Awards

Selected for Dow BEST Symposium (June 2022)
DOE Innovations in Nuclear Technology R&D First Place Award (May 2022)
CAS Future Leader (March 2022)
Selected for Pfizer Chemistry Connect (Nov 2021)
3M RISE Symposium Participant (June 2021)
NNSA SSAP Symposium Outstanding Poster Award (Feb 2021)
Department of Energy Innovations in Nuclear Technology R&D Second Place Award (June 2019)
Department of Energy National Nuclear Security Administration Stewardship Science Graduate Fellowship Awardee (March 2019)
Department of Defense SMART (Science, Mathematics, and Research for Transformation) Scholarship Semifinalist (March 2019)
National Defense Science and Engineering Graduate Fellowship Program Alternate (April 2018)
National Science Foundation Graduate Research Fellowship Program Honorable Mention (April 2018)
Ryan Fellowship from Northwestern University (Sept 2017)
Summa cum laude, Rowan University (May 2017)
Michael Miller Award for Excellence in Chemistry (May 2017)
National Science Foundation Graduate Research Fellowship Program Honorable Mention (March 2017)
American Chemical Society Undergraduate Inorganic Chemistry Award (May 2016)
Barry Goldwater Scholarship Honorable Mention (March 2016)
1st Prize recipient in Mid-Atlantic Pharmacology Society Undergraduate Poster Session (Oct 2014)
1st Prize recipient in Cooper Medical School of Rowan University Pre-Medical Urban Leadership Summer Experience Poster Session (July 2014 )
Rowan Scholars Program Scholarship (Fall 2013)
Inducted into American Christian Honor Society (Spring 2013)
Rowan University President's Scholar of Excellence (Fall 2016- Spring 2017)
Rowan University Dean's List (Fall 2016- Spring 2017)