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The Genesis Mission: Nation-Scale AI and the Future of Scientific Work

Presenter:
Brian
Spears
University:
U.S. Department of Energy National Nuclear Security Administration; Lawrence Livermore National Laboratory
Program:
SSGF
Year:
2026

Genesis Mission is a Department of Energy AI effort aimed at recruiting cutting-edge AI for science in order to double US R&D productivity while delivering innovation overmatch: the ability to mitigate emerging threats on timescales faster than those of U.S. adversaries. The effort is organized around two coupled thrusts. The first is a set of Science and Technology Challenges that define high-value problems across science, national security, and applied energy, thereby providing the mission pull for development. The second is the Genesis Platform, a federated, agent-first platform that connects frontier AI models, trusted data, high-performance computing, laboratory facilities, and mission workflows through governed and reusable interfaces.

This talk will describe the top-level goals and architecture of Genesis. We will present examples and demonstrations spanning national security, applied energy, and scientific discovery to illustrate how AI-enabled workflows can transform analysis, orchestration, and decision-making across heterogeneous computational and experimental environments.

Even more importantly, we will discuss the impact AI will have on the next generation of scientific professionals. We will touch the tremendous opportunities for early-career scientists, the obligations they carry in the midst of this revolution, and the risks they must attend to.