Mark Maienschein-Cline

My research has recently been focused on analysis of high-throughput biological data. I am working both on the independent analysis of ChIP-seq (Chromatin ImmunoPrecipitation sequencing, used to find protein-DNA binding sites) and DNA microarray (used to measure the expression level of many different genes). Additionally, I am investigating methods of combining the two data types to get insights into the biological processes that are not possible from either method alone. The research project is looking at B cell development, particularly the role of Irf4 and related transcription factors in the differentiation of activated B cells to germinal centers and plasma cells.

I have also recently worked on simple models of gene regulatory networks, with an aim to understand how intrinsic noise and perturbations to the networks can be used to systematically identify certain key features. For example, a recent study (Maienschein-Cline M, Warmflash A, Dinner A, IET Systems Biology, in preparation) proposed a method of measuring transcription factor cooperativity using intrinsic noise.

M Maienschein-Cline, CH Londergan. "The CN Stretching Band of Aliphatic Thiocyanate is Sensitive to Solvent Dynamics and Specific Solvation", J Phys Chem A, 111:10020, 2007.

CH Londergan, M Maienschein-Cline, C Reynoso. "Cysteine-based Vibrational Probes of Structure and Local Environment", Biophys J, 161A, 2007.

BL FitzPatrick, M Maienschein-Cline, LJ Butler, S-H Lee, JJ Lin. "Determining the Partial Photoionization Cross-Sections of Ethyl Radicals", J Phys Chem B, 111, 2007.

PK Whitman, DE Hahn, TE Soules, MA Norton, SN Dixit, EE Donohue, JA Folta, WG Hollingsworth, M Maienschein-Cline. "Performance of thin borosilicate glass sheets at 351 nm", Proceedings of SPIE, 333:5647, 2004.